Data on a novel liver bioscaffold (rDLS) generated from regenerative liver with activated extracellular matrix for functional liver regeneration

Extracellular matrix and liver disease.

SIGNIFICANCE The extracellular matrix (ECM) is a dynamic microenvironment that undergoes continuous remodeling, particularly during injury and wound healing. Chronic liver injury of many different etiologies such as viral hepatitis, alcohol abuse, drug-induced liver injury, obesity and insulin resistance, metabolic disorders, and autoimmune disease is characterized by excessive deposition of EC...

Circulating Extracellular RNA Markers of Liver Regeneration

BACKGROUND AND AIMS Although a key determinant of hepatic recovery after injury is active liver regeneration, the ability to detect ongoing regeneration is lacking. The restoration of liver mass after hepatectomy involves systemic changes with coordinated changes in gene expression guiding regenerative responses, activation of progenitor cells, and proliferation of quiescent hepatocytes. We pos...

Liver regeneration after liver transplantation.

BACKGROUND/PURPOSE The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation. METHODS Relevant studies were reviewed using Medline, PubMed and Springer databases. RESULTS A variety of cytokines (such as interleukin-6 and tumor necrosis factor-α), growth...

Isolating Extracellular Matrix by Liver Decellularization

INTRODUCTION Liver Fibrosis is the 12th most leading cause of the death in the United States and 45% of all deaths in the developing world are caused by a fibrotic disease. [1] With the increase rate in fibrotic disease, there is an increased need for transplants which is exceeding the number of donors available. Fibrosis in the liver remains silent until it reaches the stage of liver failure, ...

Liver Regeneration in Rats after Liver Resection and Small-for-size Liver Transplantation from Living Donors